Rational and objectives: The effects of electrolytes, viscosity, and chemotoxicity of a plasma-isotonic iodine contrast medium iodixanol were compared with regard to its propensity to cause ventricular fibrillation (VF).
Materials and methods: The left coronary artery of pigs was perfused with five isotonic solutions: iodixanol 320 mg I/mL with 19 mmol/L NaCl + 0.3 mmol/L CaCl2, Iod 320+Mann (iodixanol 320 mg I/mL + 50 mmol/L mannitol), Mann+Na/Ca (240 mmol/L mannitol with 19 mmol/L NaCl + 0.3 mmol/L CaCl2), Mann (275 mmol/L mannitol) and Ringer. The first two solutions have at 37 degrees C a viscosity of approximately 13 mPa x s while the others have a viscosity < 1 mPa x s. In eight pigs, each test solution was injected twice into the left coronary artery in random order for 10 seconds (injection volume, 20 mL). In 15 pigs, each of the solutions was injected in random order for 11-40 seconds through the end-hole of a wedged 5F balloon catheter in left coronary artery. Injection rate was 0.5 mL/sec until VF occurred. If VF occurred, injection was stopped and the heart was defibrillated. If VF did not occur, the perfusion period was 40 seconds.
Results: The 10-second perfusions caused no VF. The 40-second perfusions with iodixanol 320 mg I/mL with 19 mmol/L NaCl + 0.3 mmol/L CaCl2 or Ringer caused no VF (0%). Iod 320+Mann caused nine VF (60%) after 35 +/- 4 seconds (SEM). Mann+Na/Ca caused 14 VF (93%) after 30 +/- 2 seconds. Mann caused 15 VF (100%) after 24 +/- 2 seconds. Iodixanol 320 mg I/mL with 19 mmol/L NaCl + 0.3 mmol/L CaCl2 and Ringer caused fewer VF than all other solutions (P < .05-.001). Iod 320+Mann caused fewer VF than Mann (P < .05). Iod 320+Mann caused VF later than Mann+Na/Ca or Mann (P < .02 and P < .01). Mann+Na/Ca caused VF later than Mann (P < .05).
Conclusion: The results fit with a concept that VF starts when the electrolyte composition of the interstitial fluid in the myocardium is sufficiently nonphysiologic. The more physiologic the electrolyte composition of the perfusion fluid, and the higher its viscosity, the slower the composition of the interstitial fluid will be changed, and VF will occur later (or not at all).